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Stress, Resilience, and the Brain–Gut Axis

Why is Psychogastroenterology Important for all Digestive Disorders?
Published:October 19, 2022DOI:https://doi.org/10.1016/j.gtc.2022.07.001

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      References

        • Mehta N.
        Mind-body Dualism: A critique from a Health Perspective.
        Mens Sana Monogr. 2011; 9: 202-209
        • Drossman D.A.
        Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV.
        Gastroenterology. 2016; 150: 1262-1279.e2
        • Engel G.L.
        The need for a new medical model: a challenge for biomedicine.
        Science. 1977; 196: 129-136
        • Duncan G.
        Mind-body dualism and the biopsychosocial model of pain: what did Descartes really say?.
        J Med Philos. 2000; 25: 485-513
        • Schmulson M.J.
        • Drossman D.A.
        What Is New in Rome IV.
        J Neurogastroenterol Motil. 2017; 23: 151-163
        • Van Oudenhove L.
        • Levy R.L.
        • Crowell M.D.
        • et al.
        Biopsychosocial Aspects of Functional Gastrointestinal Disorders: How Central and Environmental Processes Contribute to the Development and Expression of Functional Gastrointestinal Disorders.
        Gastroenterology. 2016; 150: 1355-1367.e2
        • Feingold J.
        • Murray H.B.
        • Keefer L.
        Recent Advances in Cognitive Behavioral Therapy For Digestive Disorders and the Role of Applied Positive Psychology Across the Spectrum of GI Care.
        J Clin Gastroenterol. 2019; 53: 477-485
        • Kinsinger S.W.
        • Ballou S.
        • Keefer L.
        Snapshot of an integrated psychosocial gastroenterology service.
        World J Gastroenterol. 2015; 21: 1893-1899
        • Riehl M.E.
        • Kinsinger S.
        • Kahrilas P.J.
        • et al.
        Role of a health psychologist in the management of functional esophageal complaints.
        Dis Esophagus. 2015; 28: 428-436
        • Keefer L.
        Behavioural medicine and gastrointestinal disorders: the promise of positive psychology.
        Nat Rev Gastroenterol Hepatol. 2018; 15: 378-386
        • Taft T.H.
        • Keefer L.
        • Artz C.
        • et al.
        Perceptions of illness stigma in patients with inflammatory bowel disease and irritable bowel syndrome.
        Qual Life Res. 2011; 20: 1391-1399
        • Feingold J.H.
        • Drossman D.A.
        Deconstructing stigma as a barrier to treating DGBI: Lessons for clinicians.
        Neurogastroenterology Motil. 2021; 33: e14080
        • Mayer E.A.
        • Tillisch K.
        The brain-gut axis in abdominal pain syndromes.
        Annu Rev Med. 2011; 62: 381-396
        • Porges S.W.
        The Polyvagal theory: Neurophysiological Foundations of emotions, Attachment, communication, and self-Regulation.
        W.W. Norton & Company, 2011
        • Aziz I.
        • Simrén M.
        The overlap between irritable bowel syndrome and organic gastrointestinal diseases.
        Lancet Gastroenterol Hepatol. 2021; 6: 139-148
        • Halpin S.J.
        • Ford A.C.
        Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: systematic review and meta-analysis.
        Am J Gastroenterol. 2012; 107: 1474-1482
        • Fairbrass K.M.
        • Costantino S.J.
        • Gracie D.J.
        • et al.
        Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis.
        Lancet Gastroenterol Hepatol. 2020; 5: 1053-1062
        • Sperber A.D.
        • Bangdiwala S.I.
        • Drossman D.A.
        • et al.
        Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study.
        Gastroenterology. 2020; https://doi.org/10.1053/j.gastro.2020.04.014
        • Lackner J.M.
        • Jaccard J.
        • Krasner S.S.
        • et al.
        How does cognitive behavior therapy for irritable bowel syndrome work? A mediational analysis of a randomized clinical trial.
        Gastroenterology. 2007; 133: 433-444
        • McFarlane A.C.
        Stress-related musculoskeletal pain.
        Best Pract Res Clin Rheumatol. 2007; 21: 549-565
        • Viero F.T.
        • Rodrigues P.
        • Trevisan G.
        Cognitive or daily stress association with headache and pain induction in migraine and tension-type headache patients: a systematic review.
        Expert Rev Neurother. 2022; https://doi.org/10.1080/14737175.2022.2041414
        • Chen E.
        • Miller G.E.
        Stress and inflammation in exacerbations of asthma.
        Brain Behav Immun. 2007; 21: 993-999
        • Pouwer F.
        • Kupper N.
        • Adriaanse M.C.
        Does emotional stress cause type 2 diabetes mellitus? A review from the European Depression in Diabetes (EDID) Research Consortium.
        Discov Med. 2010; 9: 112-118
        • Scott K.A.
        • Melhorn S.J.
        • Sakai R.R.
        Effects of Chronic Social Stress on Obesity.
        Curr Obes Rep. 2012; 1: 16-25
        • Batty G.D.
        • Russ T.C.
        • Stamatakis E.
        • et al.
        Psychological distress and risk of peripheral vascular disease, abdominal aortic aneurysm, and heart failure: pooling of sixteen cohort studies.
        Atherosclerosis. 2014; 236: 385-388
        • Nabi H.
        • Kivimäki M.
        • Batty G.D.
        • et al.
        Increased risk of coronary heart disease among individuals reporting adverse impact of stress on their health: the Whitehall II prospective cohort study.
        Eur Heart J. 2013; 34: 2697-2705
        • Nakamura K.
        • Sheps S.
        • Arck P.C.
        Stress and reproductive failure: past notions, present insights and future directions.
        J Assist Reprod Genet. 2008; 25: 47-62
        • Meerveld B.G.V.
        • Johnson A.C.
        Mechanisms of Stress-induced Visceral Pain.
        J Neurogastroenterol Motil. 2018; 24: 7-18
        • Reinhardt T.
        • Kleindienst N.
        • Treede R.D.
        • et al.
        Individual Modulation of Pain Sensitivity under Stress.
        Pain Med. 2013; 14: 676-685
        • Taché Y.
        • Mönnikes H.
        • Bonaz B.
        • et al.
        Role of CRF in stress-related alterations of gastric and colonic motor function.
        Ann N Y Acad Sci. 1993; 697: 233-243
        • Stengel A.
        • Taché Y.
        Neuroendocrine Control of the Gut During Stress: Corticotropin-Releasing Factor Signaling Pathways in the Spotlight.
        Annu Rev Physiol. 2009; 71: 219-239
        • Lyte M.
        • Vulchanova L.
        • Brown D.R.
        Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions.
        Cell Tissue Res. 2011; 343: 23-32
        • Fass R.
        • Naliboff B.D.
        • Fass S.S.
        • et al.
        The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease.
        Gastroenterology. 2008; 134: 696-705
        • Yamasaki T.
        • Tomita T.
        • Takimoto M.
        • et al.
        Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals.
        J Neurogastroenterol Motil. 2017; 23: 526-532
        • Broers C.
        • Melchior C.
        • Van Oudenhove L.
        • et al.
        The effect of intravenous corticotropin-releasing hormone administration on esophageal sensitivity and motility in health.
        Am J Physiol Gastrointest Liver Physiol. 2017; 312: G526-G534
        • Bernstein C.N.
        • Singh S.
        • Graff L.A.
        • et al.
        A Prospective Population-Based Study of Triggers of Symptomatic Flares in IBD.
        Official J Am Coll Gastroenterol ACG. 2010; 105: 1994-2002
        • Bernstein C.N.
        The Brain-Gut Axis and Stress in Inflammatory Bowel Disease.
        Gastroenterol Clin North Am. 2017; 46: 839-846
        • Chang L.
        The role of stress on physiologic responses and clinical symptoms in irritable bowel syndrome.
        Gastroenterology. 2011; 140: 761-765
        • Ng J.Y.Y.
        • Ntoumanis N.
        • Thøgersen-Ntoumani C.
        • et al.
        Self-Determination Theory Applied to Health Contexts: A Meta-Analysis.
        Perspect Psychol Sci. 2012; 7: 325-340
        • Charmaz K.
        The Body, Identity, and Self: Adapting To Impairment.
        Sociological Q. 1995; 36: 657-680
        • Drossman D.A.
        • Tack J.
        • Ford A.C.
        • et al.
        Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut−Brain Interaction): A Rome Foundation Working Team Report.
        Gastroenterology. 2018; 154: 1140-1171.e1
        • Mikocka-Walus A.
        • Ford A.C.
        • Drossman D.A.
        Antidepressants in inflammatory bowel disease.
        Nat Rev Gastroenterol Hepatol. 2020; 17: 184-192
        • Keefer L.
        • Ballou S.K.
        • Drossman D.A.
        • et al.
        A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction.
        Gastroenterology. 2021; https://doi.org/10.1053/j.gastro.2021.09.015
        • Russo S.J.
        • Murrough J.W.
        • Han M.H.
        • et al.
        Neurobiology of resilience.
        Nat Neurosci. 2012; 15: 1475-1484
        • Park S.H.
        • Naliboff B.D.
        • Shih W.
        • et al.
        Resilience is decreased in irritable bowel syndrome and associated with symptoms and cortisol response.
        Neurogastroenterol Motil. 2018; 30https://doi.org/10.1111/nmo.13155
        • Parker C.H.
        • Naliboff B.D.
        • Shih W.
        • et al.
        The Role of Resilience in Irritable Bowel Syndrome, Other Chronic Gastrointestinal Conditions, and the General Population.
        Clin Gastroenterol Hepatol. 2021; 19: 2541-2550.e1
        • Keefer L.
        • Blanchard E.B.
        The effects of relaxation response meditation on the symptoms of irritable bowel syndrome: results of a controlled treatment study.
        Behav Res Ther. 2001; 39: 801-811
        • Kuo B.
        • Bhasin M.
        • Jacquart J.
        • et al.
        Genomic and clinical effects associated with a relaxation response mind-body intervention in patients with irritable bowel syndrome and inflammatory bowel disease.
        PLoS One. 2015; 10: e0123861
        • Feingold J.H.
        • Kaye-Kauderer H.
        • Mendiolaza M.
        • et al.
        Empowered transitions: Understanding the experience of transitioning from pediatric to adult care among adolescents with inflammatory bowel disease and their parents using photovoice.
        J Psychosomatic Res. 2021; 143: 110400
        • Slonim-Nevo V.
        • Sarid O.
        • Friger M.
        • et al.
        Effect of Social Support on Psychological Distress and Disease Activity in Inflammatory Bowel Disease Patients.
        Inflamm Bowel Dis. 2018; 24: 1389-1400
        • Lackner J.M.
        • Brasel A.M.
        • Quigley B.M.
        • et al.
        The ties that bind: perceived social support, stress, and IBS in severely affected patients: Support, stress, and IBS.
        Neurogastroenterology Motil. 2010; 22: 893-900
        • Owens D.M.
        • Nelson D.K.
        • Talley N.J.
        The irritable bowel syndrome: long-term prognosis and the physician-patient interaction.
        Ann Intern Med. 1995; 122: 107-112
        • Jayaraman T.
        • Wong R.K.
        • Drossman D.A.
        • et al.
        Communication breakdown between physicians and IBS sufferers: what is the conundrum and how to overcome it?.
        J R Coll Physicians Edinb. 2017; 47: 138-141
        • Keefer L.
        • Gorbenko K.
        • Siganporia T.
        • et al.
        Resilience-based Integrated IBD Care Is Associated With Reductions in Health Care Use and Opioids.
        Clin Gastroenterol Hepatol. 2021; (S1542356521012258)https://doi.org/10.1016/j.cgh.2021.11.013
        • Ford A.
        • Lacy B.
        • Harris L.
        • et al.
        Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis.
        Am J Gastroenterol. 2019; 114: 21-39
        • Keefer L.
        • Palsson O.S.
        • Pandolfino J.E.
        Best Practice Update: Incorporating Psychogastroenterology Into Management of Digestive Disorders.
        Gastroenterology. 2018; 154: 1249-1257
        • Rodrigues D.M.
        • Motomura D.I.
        • Tripp D.A.
        • et al.
        Are psychological interventions effective in treating functional dyspepsia? A systematic review and meta-analysis.
        J Gastroenterol Hepatol. 2021; 36: 2047-2057
        • Timmer A.
        • Preiss J.C.
        • Motschall E.
        • et al.
        Psychological interventions for treatment of inflammatory bowel disease.
        Cochrane Database Syst Rev. 2011; : CD006913
        • Keefer L.
        • Doerfler B.
        • Artz C.
        Optimizing management of Crohn’s disease within a project management framework: results of a pilot study.
        Inflamm Bowel Dis. 2012; 18: 254-260
        • Riehl M.E.
        • Pandolfino J.E.
        • Palsson O.S.
        • et al.
        Feasibility and acceptability of esophageal-directed hypnotherapy for functional heartburn.
        Dis Esophagus. 2016; 29: 490-496
        • Windgassen S.
        • Moss-Morris R.
        • Goldsmith K.
        • et al.
        Key mechanisms of cognitive behavioural therapy in irritable bowel syndrome: The importance of gastrointestinal related cognitions, behaviours and general anxiety.
        J Psychosomatic Res. 2019; 118: 73-82
        • Bernabeu P.
        • van-der Hofstadt C.
        • Rodríguez-Marín J.
        • et al.
        Effectiveness of a Multicomponent Group Psychological Intervention Program in Patients with Inflammatory Bowel Disease: A Randomized Trial.
        Int J Environ Res Public Health. 2021; 18: 5439
        • Drossman D.A.
        • Ruddy J.
        Improving Patient-Provider Relationships to Improve Health Care.
        Clin Gastroenterol Hepatol. 2020; 18: 1417-1426
        • Weiland A.
        • Van de Kraats R.E.
        • Blankenstein A.H.
        • et al.
        Encounters between medical specialists and patients with medically unexplained physical symptoms; influences of communication on patient outcomes and use of health care: a literature overview.
        Perspect Med Educ. 2012; 1: 192-206
        • Drossman D.A.
        2012 David Sun Lecture: Helping Your Patient by Helping Yourself—How to Improve the Patient–Physician Relationship by Optimizing Communication Skills.
        Official J Am Coll Gastroenterol ACG. 2013; 108: 521-528
        • Beck R.S.
        • Daughtridge R.
        • Sloane P.D.
        Physician-patient communication in the primary care office: a systematic review.
        J Am Board Fam Pract. 2002; 15: 25-38